Key result
Local recurrence of retroperitoneal liposarcoma is linked to ~93% higher mortality risk versus distant recurrence.
Why the study?
The clinical profiles of recurrent retroperitoneal liposarcoma needed to be explored, as recurrence patterns remained controversial and ambiguous.
Does distant recurrence pattern compared to local recurrence pattern affect overall survival and recurrence-free survival in patients with recurrent retroperitoneal liposarcoma?
Cohort (n=138)
No
Does distant recurrence pattern compared to local recurrence pattern affect overall survival and recurrence-free survival in patients with recurrent retroperitoneal liposarcoma?
Effect estimate: HR 1.934 (95% CI 1.212-3.085)
p-value: p=0.006
In patients with recurrent retroperitoneal liposarcoma, a distant recurrence pattern is associated with a better prognosis compared to a local recurrence pattern, suggesting that aggressive combined resection may be particularly beneficial for these patients.
This is the authors' abstract. We don't add key points for this paper.
BACKGROUND: The clinical profiles of recurrent retroperitoneal liposarcoma (RLS) need to be explored. The recurrence patterns of RLS are controversial and ambiguous. METHODS: A total of 138 patients with recurrent RLS were finally recruited in the study. The analysis of overall survival (OS) and recurrence-free survival (RFS) was performed by Kaplan‒Meier analysis. To identify independent prognostic factors, all significant variables on univariate Cox regression analysis (P ≤ 0.05) were subjected to multivariate Cox regression analysis. The corresponding nomogram model was further built to predict the survival status of patients. RESULTS: Among patients, the 1-, 3-, and 5-year OS rates were 70.7%, 35.9% and 30.9%, respectively. The 1-, 3- and 5-year RFS rates of the 55 patients who underwent R0 resection were 76.1%, 50.8% and 34.4%, respectively. The multivariate analysis revealed that resection method, tumor size, status of pathological differentiation, pathological subtypes and recurrence pattern were independent risk factors for OS or RFS. Patients with distant recurrence (DR) pattern usually had multifocal tumors (90.5% vs. 74.7%, P < 0.05); they were prone to experience changes of pathological differentiation (69.9% vs. 33.3%, P < 0.05) and had a better prognosis than those with local recurrence (LR) pattern. R0 resection and combined organ resection favored the survival of patients with DR pattern in some cases. CONCLUSIONS: Patients with DR pattern had better prognosis, and they may benefit more from aggressive combined resection than those with LR pattern. Classifying the recurrence patterns of RLS provides guidance for individualized clinical management of recurrent RLS.
Recurrence pattern may aid prognostic assessment in recurrent retroperitoneal liposarcoma; leaves open whether it should guide resection strategy.
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Deng et al. (2023) conducted a cohort in Recurrent retroperitoneal liposarcoma (RLS) (n=138). Local recurrence (LR) pattern vs. Distant recurrence (DR) pattern was evaluated on 5-year Overall Survival (OS) (HR 1.934, 95% CI 1.212-3.085, p=0.006). Local recurrence of retroperitoneal liposarcoma was associated with a significantly higher risk of mortality compared to distant recurrence (HR 1.934).
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