Key result
Primary retroperitoneal liposarcoma linked to ~25% higher absolute five-year overall survival versus local recurrent disease.
Why the study?
The study was conducted to compare the clinical characteristics of primary and local recurrent retroperitoneal liposarcoma cases and determine factors involved in postoperative survival.
What are the prognostic factors for overall survival and progression-free survival in patients undergoing surgery for primary versus local recurrent retroperitoneal liposarcoma?
Cohort (n=90)
No
What are the prognostic factors for overall survival and progression-free survival in patients undergoing surgery for primary versus local recurrent retroperitoneal liposarcoma?
Absolute Event Rate: 45.7% vs 20.5%
p-value: p=0.004
Complete surgical resection and tumor grade are critical prognostic factors for survival in patients with retroperitoneal liposarcoma.
Clinicopathological factors in RPLPS surgery remain unclear; leaves open validated prognostic models for recurrent disease.
Aim: The clinical characteristics of primary retroperitoneal liposarcoma(PR RPLPS) and local recurrent retroperitoneal liposarcoma(LR RPLPS) cases were compared to determine related factors involved in postoperative survival.Methods: A total of 90 patients who underwent surgery between 2006 and 2013 were included in this study. Clinicopathological data that was prospectively gathered was analyzed to identify factors associated with overall survival and progression-free survival.Results: The PR cases showed a higher complete resection rate when compared to the LR group. The LR group showed a greater number that were poorly differentiated and highly malignant. More blood loss was observed in the LR compared to the PR group. Multivariate analysis suggested that blood loss and tumor grade were prognostic factors for OS and PFS of the PR group, but extent of resection was a prognostic factor only for OS. In the LR group, the extent of resection was a significant prognostic factor associated with OS, whereas tumor grade was associated with PFS.Conclusions: Complete surgical resection is the most important factor for the survival of RPLPS patients. Tumor grade is an independent prognostic factor for PFS. In PR RPLPS, poor tumor classification and increased intraoperative bleeding are associated with a poor prognosis.
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Yan et al. (2020) conducted a cohort in Retroperitoneal liposarcoma (n=90). Primary retroperitoneal liposarcoma vs. Local recurrent retroperitoneal liposarcoma was evaluated on 5-year overall survival (p=0.004). Primary retroperitoneal liposarcoma was associated with a significantly higher 5-.
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