What question did this study set out to answer?

To review surgical outcomes, local recurrence rates, and disease-specific survival in patients treated for primary and recurrent retroperitoneal liposarcoma.

November 12, 2004British journal of surgery

Surgical management of primary and recurrent retroperitoneal liposarcoma

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Why the study?

What are the outcomes of surgical management for primary and recurrent retroperitoneal liposarcoma?

Population

119 patients treated at the Royal Marsden Hospital since 1990

Design

Cohort

Follow-up

Median 26 months for primary; median 68 months for recurrent

Authors

SNSusan J. NeuhausThe University of Adelaide PBPeter BarryNorthern General Hospital MCMatthew A. ClarkBVI (United States)

Discussion

Member takes

Implication

May support complete resection for low-grade primary RPLS; leaves open optimal management of recurrent disease.

Key Points

To review surgical outcomes, local recurrence rates, and disease-specific survival in patients treated for primary and recurrent retroperitoneal liposarcoma.
Retrospective review of medical records for patients undergoing surgery for retroperitoneal liposarcoma (RPLS) since 1990 at the Royal Marsden Hospital.
Analyzed 72 patients with primary RPLS and 47 patients undergoing palliative surgery for recurrent RPLS as distinct cohorts.
Among 72 primary RPLS cases (over 50% requiring contiguous organ resection for clearance), 34 of 58 patients with ≥12 months follow-up showed no recurrence at a median follow-up of 26 (range 12–151) months.
Low-grade histology and macroscopic tumor clearance were significantly associated with decreased local recurrence risk and improved overall survival.
For 47 recurrent RPLS patients undergoing palliative surgery, median survival from the last operation to death was 27 (range 0–79) months over a median follow-up of 68 (range 14–261) months.

Structured PICO

What are the outcomes of surgical management for primary and recurrent retroperitoneal liposarcoma?

Population

119 patients (72 with primary retroperitoneal liposarcoma, 47 with recurrent retroperitoneal liposarcoma) treated at the Royal Marsden Hospital since 1990

Intervention

Surgical resection (including resection of contiguous organs for clearance in primary cases, and palliative surgery for recurrent cases)

Outcome

Local recurrence and disease-specific survivalhard clinical

Complete resection of low-grade primary retroperitoneal liposarcoma offers the best prognosis, while palliative resection for recurrent disease can provide meaningful survival.

Cite This Study

Neuhaus et al. (2004) studied this question.

synapsesocial.com/papers/6a6f477ca528af2d65c2e926 https://doi.org/10.1002/bjs.4802

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Surgical management of primary and recurrent retroperitoneal liposarcoma

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Surgical management of primary and recurrent retroperitoneal liposarcoma

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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