Why the study?
Is the plasma concentration of small, dense LDL particles associated with carotid intima-media thickness in healthy middle-aged men?
Population
94 healthy, 50-year-old men, all homozygous for the apolipoprotein E3 allele
Design
Cross-sectional
Key result
Plasma concentration of the small, dense LDL-III subfraction correlated strongly with common carotid artery intima-media thickness (r=0.42, P<0.001) in healthy 50-year-old men.
Authors
Loading...
May mark early atherosclerosis risk in healthy men; hypothesis-generating and requires prospective validation.
Cross-Sectional (n=94)
Is the plasma concentration of small, dense LDL particles associated with carotid intima-media thickness in healthy middle-aged men?
Effect estimate: r=0.42
p-value: p=<0.001
Small, dense LDL particles are independently associated with increased carotid intima-media thickness, a marker of subclinical atherosclerosis, in healthy middle-aged men.
Skoglund-Andersson et al. (1999) conducted a cross-sectional in Healthy (n=94). Plasma concentration of LDL subfractions (LDL-III) was evaluated on Correlation between plasma concentration of LDL subfractions and intima-media thickness (IMT) of the common carotid artery (CCA) (r=0.42, p=<0.001). Plasma concentration of the small, dense LDL-III subfraction correlated strongly with common carotid artery intima-media thickness (r=0.42, P<0.001) in healthy 50-year-old men.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: