Key result
Small dense low-density lipoprotein concentration has a strong positive correlation with carotid intima-media thickness and serves as a superior marker for early detection of cardiovascular disease.
Why the study?
Early and accurate diagnosis of vascular thickening by predictive markers may reduce CVD and atherosclerosis mortality, prompting this examination of the relationship between sdLDL and cIMT.
Is small dense low-density lipoprotein (sdLDL) concentration associated with carotid intima-media thickness (cIMT)?
Is small dense low-density lipoprotein (sdLDL) concentration associated with carotid intima-media thickness (cIMT)?
This review highlights a positive correlation between sdLDL concentration and cIMT, suggesting their combined use for better assessment of atherosclerosis.
Cardiovascular disease (CVD) and atherosclerosis are major causes of mortality worldwide. Early and accurate diagnosis of vascular thickening by predictive markers can help reduce the death rate of these diseases. Low-density lipoprotein (LDL) particles, which are rich in cholesterol, are regarded as key biomarkers for CVD and atherosclerosis. Numerous studies have demonstrated that pattern B (small dense LDL, sdLDL) is more atherogenic than LDL and can serve as a superior quantitative marker for CVD than LDL. Furthermore, several studies have indicated that carotid intima-media thickness (cIMT) is a reliable marker for the early detection of CVD and atherosclerosis in various populations. This review examines the relationship between sdLDL concentration and cIMT. It is concluded that sdLDL concentration has a positive correlation with cIMT, and their combined use can facilitate a more precise assessment of the diseases, especially atherosclerosis.
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Khosravi et al. (2024) conducted a review in Cardiovascular disease and atherosclerosis. Small dense low-density lipoprotein (sdLDL) measurement vs. Other lipid parameters was evaluated on Carotid intima-media thickness (cIMT). Small dense low-density lipoprotein concentration has a strong positive correlation with carotid intima-media thickness and serves as a superior marker for early detection of cardiovascular disease.
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