Key result
Wide surgical resection improved the 5-year local recurrence-free rate compared to marginal resection in patients with soft-tissue sarcoma of the thigh, but did not influence overall survival.
Why the study?
Does surgical margin influence local recurrence and survival in patients with soft-tissue sarcoma of the thigh?
Cohort (n=152)
No
Does surgical margin influence local recurrence and survival in patients with soft-tissue sarcoma of the thigh?
In patients with soft-tissue sarcoma of the thigh, a wider surgical margin reduces the risk of local recurrence but does not significantly improve overall survival.
Answers are grounded in this paper and cite their sources.
May support wider margins to reduce local recurrence in thigh sarcomas; leaves open survival impact and need for randomized trials.
Between 1979 and 1998, 152 patients with a soft-tissue sarcoma arising in the thigh were surgically treated in the Sarcoma Center in Aarhus, Denmark. We studied clinicopathologic factors prognostic for local recurrence and survival. 27 patients (18%) had a low-grade tumor, 26 (17%) an intermediate-grade and 99 (65%) a high-grade tumor. 27 patients (18%) were amputated and 125 (82%) had a local resection. 21 (14%) underwent a marginal resection, 82 (54%) a wide resection and 49 (32%) a compartmental resection. 32 patients were also given radiotherapy, 11 of these had a marginal resection. The 5-year local recurrence-free rate was 91%. Multivariate analysis selected marginal resection and histological high grade as unfavorable prognostic factors for local recurrence. The 5-year survival rate was 68%. High age and histological high grade were unfavorable prognostic factors for survival in a multivariate analysis. Surgical margin influenced local recurrence, but not the overall survival.
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Vraa et al. (2001) conducted a cohort in Soft-tissue sarcoma of the thigh (n=152). Wide surgical resection vs. Marginal resection was evaluated on 5-year local recurrence-free rate (p=0.02). Wide surgical resection improved the 5-year local recurrence-free rate compared to marginal resection in patients with soft-tissue sarcoma of the thigh, but did not influence overall survival.
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