Key result
Intralesional surgical margins were associated with a significantly higher risk of local recurrence (HR 10.21) compared to wide margins, but did not significantly influence overall survival.
Why the study?
Does margin status after surgical treatment impact local recurrence and overall survival in patients with high-grade soft tissue sarcomas of the extremities?
Population
127 patients with high-grade soft tissue sarcomas of the extremities, mean age 48 years (range 5-91)
Design
Cohort
Follow-up
median 71 months
Authors
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Resection margins associated with local recurrence but not survival; leaves open whether aggressive margins improve outcomes in high-grade extremity STS.
Cohort (n=127)
Yes
Does margin status after surgical treatment impact local recurrence and overall survival in patients with high-grade soft tissue sarcomas of the extremities?
Hazard Ratio: 10.21 (95% CI 2.46–42.35)
p-value: p=0.006
In high-grade soft tissue sarcomas of the extremities, surgical margins strongly influence local recurrence but not overall survival, whereas tumor size impacts both.
Willeumier et al. (2015) conducted a cohort in High-grade soft tissue sarcomas of the extremities (n=127). Intralesional surgical margins vs. Wide surgical margins (>2 mm) was evaluated on Local recurrence (HR 10.21, 95% CI 2.46-42.35, p=0.006). Intralesional surgical margins were associated with a significantly higher risk of local recurrence (HR 10.21) compared to wide margins, but did not significantly influence overall survival.
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