Lymph Node Metastasis From Soft Tissue Sarcoma in Adults Analysis of Data From a Prospective Database of 1772 Sarcoma Patients
Key result
Radical lymphadenectomy for isolated lymph node metastasis from sarcoma was associated with a 16.3-month median survival compared to 4.3 months for less than curative procedures.
Why the study?
Does radical lymphadenectomy improve survival in adult patients with lymph node metastasis from soft tissue sarcoma?
Population
1772 adult sarcoma patients from a prospective database, of which 46 had lymph node metastasis.
Comparison
Radical, therapeutic lymphadenectomy with… vs Less than curative procedures, in most cases…
Design
Cohort
Follow-up
Median 12.9 months (range, 0 to 100 months)
Authors
Discussion
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Implication
May support selective use in isolated nodal sarcoma; hypothesis-generating and requires prospective validation.
Study Design
Type
Cohort (n=1,772)
Structured PICO
Does radical lymphadenectomy improve survival in adult patients with lymph node metastasis from soft tissue sarcoma?
P
Population
1772 adult sarcoma patients from a prospective database (July 1982 to July 1991), of which 46 (2.6%) had lymph node metastasis.
I
Intervention
Radical, therapeutic lymphadenectomy with curative intent (n=31)
C
Comparator
Less than curative procedures, in most cases biopsy only (n=15)
O
Outcome
Survival (median survival and 5-year survival)hard clinical
Main Result
Absolute Event Rate: 16.3% vs 4.3%
Radical lymphadenectomy for isolated regional lymph node metastasis from soft tissue sarcoma in adults is associated with improved median survival and potential for long-term survival.
Cite This Study
Fong et al. (1993) conducted a cohort in Soft tissue sarcoma (n=1,772). Radical therapeutic lymphadenectomy vs. Less than curative procedures (mostly biopsy only) was evaluated on Median survival (months). Radical lymphadenectomy for isolated lymph node metastasis from sarcoma was associated with a 16.3-month median survival compared to 4.3 months for less than curative procedures.