Key result
PCR-directed sequence analysis of a t(11;22) translocation in Ewing's sarcoma revealed an asymmetric junction and a novel EWS/FLII chimeric product flanked by a palindromic hexamer.
Population
A case of Ewing's sarcoma with t(11;22)(q24;q12) translocation
Design
Case_report
Authors
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Case report of novel EWS/FLI1 junction leaves open functional role of palindromic hexamer; requires validation in additional Ewing sarcoma cases.
Case Report (n=1)
Molecular analysis of a Ewing's sarcoma case revealed an asymmetric junction and a palindromic hexamer flanking the breakpoints, suggesting functional significance in the genesis of the t(11;22) translocation.
Bhagirath et al. (1995) conducted a case report in Ewing's sarcoma (n=1). PCR-directed sequence analysis of a t(11;22) translocation in Ewing's sarcoma revealed an asymmetric junction and a novel EWS/FLII chimeric product flanked by a palindromic hexamer.
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