Population
Three Ewing tumors (ET), two with apparently normal chromosomes 21 and 22, and one ET with a t(2;22)(p25;q12)
Design
Preclinical
Authors
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May support FISH detection of cryptic EWS/ERG fusions in Ewing tumors; leaves open the inversion-insertion mechanism pending validation.
Double-target FISH using probes flanking the EWS breakpoint region and probe PT1526 enables reliable detection of cytogenetically undetectable EWS/ERG fusions in Ewing tumors.
Hattinger et al. (2001) studied this question.
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