Key result
Among 85 small blue round cell tumors, 7 (8.2%) harbored FUS gene rearrangements, highlighting the need for additional molecular testing beyond standard EWSR1 FISH assays.
Population
85 small blue round cell tumors (SBRCTs)
Design
Cohort
Authors
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Relying solely on EWSR1 FISH may miss FUS-rearranged tumors; leaves open optimal testing algorithms in small blue round cell tumors.
Observational (n=85)
Relying solely on EWSR1 FISH assay for Ewing sarcoma diagnosis can miss EWSR1-ERG fusions, highlighting the need for additional molecular testing like ERG FISH or NGS in classic cases.
Chen et al. (2015) conducted an observational in Small blue round cell tumors (SBRCTs) (n=85). FUS and ERG gene rearrangements was evaluated on Prevalence of FUS gene rearrangements. Among 85 small blue round cell tumors, 7 (8.2%) harbored FUS gene rearrangements, highlighting the need for additional molecular testing beyond standard EWSR1 FISH assays.
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