Key result
Preconditioning induced late protection against reperfusion-induced coronary endothelial injury, improving maximal relaxations to acetylcholine to 48% versus 31% with ischemia/reperfusion alone.
Why the study?
Does preconditioning protect against reperfusion-induced coronary endothelial injury 24 hours later in rats?
Population
Rats subjected to myocardial ischemia/reperfusion (I/R) injury.
Comparison
Preconditioning with 1 cycle of 2 minutes… vs Sham surgery or ischemia/reperfusion without…
Design
Preclinical
Follow-up
24 hours
Authors
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Hypothesis-generating for delayed endothelial protection; leaves open clinical translation to human reperfusion injury.
Does preconditioning protect against reperfusion-induced coronary endothelial injury 24 hours later in rats?
Absolute Event Rate: 48% vs 31%
Preconditioning induces delayed protection against reperfusion-induced coronary endothelial injury in rats, a process triggered by reactive oxygen species.
Kaeffer et al. (1997) studied myocardial ischemia/reperfusion injury. Preconditioning (PC) vs. Sham surgery or ischemia/reperfusion alone was evaluated on maximal relaxations to acetylcholine. Preconditioning induced late protection against reperfusion-induced coronary endothelial injury, improving maximal relaxations to acetylcholine to 48% versus 31% with ischemia/reperfusion alone.
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