Experimental human endotoxemia increases cardiac regularity

Q: What is the clinical evidence from this study?

Study design: RCT. Population: Healthy volunteers. Intervention: Intravenous Escherichia coli endotoxin with or without oral ibuprofen vs. Saline placebo. Primary outcome: Heart rate variability (standard deviation, power spectra) and regularity (approximate entropy).

Q: What does this research mean for the field?

Experimental human endotoxemia causes a significant early loss of heart rate variability and an increase in cardiac regularity, which occurs independently of clinical symptoms like fever. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

Paul Godin; Lee A. Fleisher; Alec Eidsath; R. William Vandivier; Hugh L. Preas; Steven M. Banks; Timothy G. Buchman; Anthony F. Suffredini

doi:10.1097/00003246-199607000-00009

July 1, 1996Critical Care Medicine

Experimental human endotoxemia increases cardiac regularity

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Key result

Intravenous endotoxin administration in healthy volunteers caused a significant loss of heart rate variability and an increase in heart rate regularity, even with ibuprofen pretreatment.

Why the study?

Does intravenous endotoxin reduce heart rate variability in healthy volunteers?

Key Points

This research aims to explore the relationship between human endotoxemia and the variability of heart rate.
Prospective, randomized, crossover, single-blind design
Intravenous endotoxin or saline placebo administered to healthy volunteers with or without ibuprofen
Continuous electrocardiogram recordings over 8 hours to measure R-R intervals
Endotoxin administration resulted in a significant loss of heart rate variability across all measures.
Changes in approximate entropy indicated increased cardiac regularity, occurring earlier than other variability metrics.
Ibuprofen did not prevent the loss of variability, despite blocking fever and other endotoxin symptoms.

Study Design

Type

RCT

Blinding

Single-blind

Randomization

Crossover

Multicenter

No

Structured PICO

Does intravenous endotoxin reduce heart rate variability in healthy volunteers?

P

Population

Healthy volunteers

I

Intervention

Intravenous administration of reference (Escherichia coli) endotoxin, with or without previous administration of oral ibuprofen

C

Comparator

Intravenous saline placebo, with or without previous administration of oral ibuprofen

O

Outcome

Heart rate variability measured by standard deviation, power spectra, and approximate entropy of R-R intervals over 8 hrssurrogate

Implication

Experimental human endotoxemia causes a loss of heart rate variability and an increase in heart rate regularity, which may serve as an early marker for sepsis.

Abstract

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Discussion

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Cite This Study

Godin et al. (1996) conducted an RCT in Healthy volunteers. Intravenous Escherichia coli endotoxin with or without oral ibuprofen vs. Saline placebo was evaluated on Heart rate variability (standard deviation, power spectra) and regularity (approximate entropy). Intravenous endotoxin administration in healthy volunteers caused a significant loss of heart rate variability and an increase in heart rate regularity, even with ibuprofen pretreatment.

synapsesocial.com/papers/6a0c7bb15712c53037e8ac3a https://doi.org/10.1097/00003246-199607000-00009

View at Publisher

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Experimental human endotoxemia increases cardiac regularity

Key Points

Study Design

Structured PICO

Implication

Abstract

Discussion

Cite This Study

Experimental human endotoxemia increases cardiac regularity

Key Points

Study Design

Structured PICO

Implication

Abstract

Discussion

Cite This Study

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