What question did this study set out to answer?

To evaluate the association between blood lipid levels, including fractionated cholesterol and triglycerides, and first-ever ischemic stroke or transient ischemic attack (TIA) in patients with coronary heart disease.

December 11, 2001CirculationOpen Access

Blood Lipids and First-Ever Ischemic Stroke/Transient Ischemic Attack in the Bezafibrate Infarction Prevention (BIP) Registry

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Authors

DTDavid TannéUniversity of Bern NKNira Koren‐MoragTel Aviv University EGE. GraffTel Aviv University

Discussion

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Implication

Prospective registry analysis reveals elevated triglycerides increase ischemic stroke risk in coronary heart disease, indicating a modifiable vascular target.

Key Points

To evaluate the association between blood lipid levels, including fractionated cholesterol and triglycerides, and first-ever ischemic stroke or transient ischemic attack (TIA) in patients with coronary heart disease.
Followed 11,177 patients with documented coronary heart disease and no history of stroke or TIA who were screened for the Bezafibrate Infarction Prevention study.
Assessed baseline medical histories and fasting lipid profiles at a central laboratory, tracking outcomes over a 6- to 8-year follow-up period.
Identified cerebrovascular events and evaluated risk using multivariable logistic regression models.
A total of 941 patients developed nonhemorrhagic cerebrovascular disease, with 487 confirmed cases of verified ischemic stroke or TIA.
Triglyceride levels >200 mg/dL were independently associated with an increased risk of ischemic stroke/TIA (adjusted OR 1.27, 95% CI 1.01 to 1.60).
Higher high-density lipoprotein percentage was protective, with a 5% decrease in the percentage of HDL cholesterol linked to an adjusted OR of 0.87 (95% CI 0.78 to 0.97).

Cite This Study

Tanné et al. (2001) studied this question.

synapsesocial.com/papers/6a0c951ec63d985fc0885db6 https://doi.org/10.1161/hc4901.100384

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Implication

Prospective registry analysis reveals elevated triglycerides increase ischemic stroke risk in coronary heart disease, indicating a modifiable vascular target.

Blood Lipids and First-Ever Ischemic Stroke/Transient Ischemic Attack in the Bezafibrate Infarction Prevention (BIP) Registry

Discussion

Member takes

Implication

Key Points

Cite This Study

Blood Lipids and First-Ever Ischemic Stroke/Transient Ischemic Attack in the Bezafibrate Infarction Prevention (BIP) Registry

Discussion

Member takes

Implication

Key Points

Cite This Study

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