What question did this study set out to answer?

To define the molecular mechanisms through which the androgen receptor governs cell cycle progression and drives proliferation in prostate cancer.

January 1, 2008Nuclear Receptor SignalingOpen Access

AR, the cell cycle, and prostate cancer

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To define the molecular mechanisms through which the androgen receptor governs cell cycle progression and drives proliferation in prostate cancer.
Review and synthesis of mechanistic findings regarding androgen receptor signaling, cell cycle checkpoints, and mechanisms of therapy resistance.
The androgen receptor functions as a master regulator of G1-S phase transition by promoting G1 cyclin-dependent kinase activity and inactivating the retinoblastoma tumor suppressor, independently of TMPRSS2-ETS fusions.
Cell cycle machinery reciprocally modulates androgen receptor activity across cell division phases, establishing a bidirectional regulatory circuit that can facilitate resistance to androgen deprivation.

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Implication

Narrative review uncovers crosstalk between androgen receptor signaling and cell cycle machinery in prostate cancer cells, highlighting mechanisms driving therapy-resistant tumor growth.

Cite This Study

Balk et al. (2008) studied this question.

synapsesocial.com/papers/6a0cb4f6d48675e49423aa5a https://doi.org/10.1621/nrs.06001

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Implication

Narrative review uncovers crosstalk between androgen receptor signaling and cell cycle machinery in prostate cancer cells, highlighting mechanisms driving therapy-resistant tumor growth.

AR, the cell cycle, and prostate cancer

Key Points

Discussion

Implication

Cite This Study

AR, the cell cycle, and prostate cancer

Key Points

Discussion

Implication

Cite This Study

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