Key result
Fixed-dose combinations of candesartan and hydrochlorothiazide effectively lower blood pressure and improve compliance, with higher clinical efficacy than losartan/hydrochlorothiazide.
Why the study?
Does a fixed-dose combination of candesartan and hydrochlorothiazide improve blood pressure control and compliance in patients with hypertension?
Population
Patients with hypertension, including elderly patients and those with diabetes, heart failure, or stroke
Comparison
Fixed-dose combination of candesartan cilexetil… vs Losartan/hydrochlorothiazide or non-RAS blocking…
Design
Review
Authors
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May support candesartan/HCTZ combinations to improve compliance; leaves open superiority over losartan/HCTZ pending RCTs.
Does a fixed-dose combination of candesartan and hydrochlorothiazide improve blood pressure control and compliance in patients with hypertension?
Fixed-dose combinations of candesartan and hydrochlorothiazide offer an effective, well-tolerated option for hypertension management that may improve patient compliance.
Thomas Mengden (2009) conducted a review in Hypertension. candesartan/hydrochlorothiazide fixed dose combination vs. losartan/hydrochlorothiazide was evaluated. Fixed-dose combinations of candesartan and hydrochlorothiazide effectively lower blood pressure and improve compliance, with higher clinical efficacy than losartan/hydrochlorothiazide.
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