Key result
ASA scores 4-5 are linked to ~575% higher risk of failure to rescue from anastomotic leak.
Why the study?
Failure to rescue has been recognized as a critical factor influencing outcomes in colorectal surgery, particularly after major complications like anastomotic leak, but its rate, impact, and independent predictors required evaluation.
Population
31,610 patients undergoing colorectal resection with primary anastomosis
Comparison
Patients with failure to rescue following anastomotic leak vs those rescued or without anastomotic leak
Design
Retrospective registry-based observational study
Follow-up
In-hospital or 30-day
Authors
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May inform perioperative risk assessment in colorectal resection; leaves open whether targeted interventions reduce failure-to-rescue mortality.
Observational (n=31,610)
Yes
In patients undergoing colorectal cancer resection, anastomotic leak contributes to over 20% of postoperative deaths, with failure to rescue independently predicted by older age, high ASA score, and sepsis.
Wells et al. (2025) conducted an observational in Colorectal cancer (n=31,610). Anastomotic leak was evaluated on Failure to rescue from anastomotic leak (FTR-AL), defined as in-hospital or 30-day mortality following AL. Failure to rescue from anastomotic leak occurred in 5.9% of patients and was independently predicted by older age, ASA score of 4-5 (OR 6.75), and sepsis (OR 3.32).
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