What question did this study set out to answer?

To comprehensively evaluate the mechanisms of ammonia metabolism dysregulation, ammonia-induced cell death, and their therapeutic implications in oncology.

October 30, 2025Cell Communication and SignalingOpen Access

Ammonia metabolism and ammonia-induced cell death: role in cancer therapy

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Authors

YXYan XuCincinnati Children's Hospital Medical Center JWJiafeng WangZhejiang International Studies University AWAiguo WuNingbo University

Discussion

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Implication

Narrative review uncovers the role of ammonia metabolism and selective immune cell death in the tumor microenvironment, highlighting novel metabolic and immunotherapeutic strategies.

Key Points

To comprehensively evaluate the mechanisms of ammonia metabolism dysregulation, ammonia-induced cell death, and their therapeutic implications in oncology.
Systematically reviewed literature on ammonia generation and clearance pathways, including the urea cycle and tumor glutamine metabolism.
Analyzed the molecular networks linking ammonia accumulation to mitochondrial dysfunction, lysosomal stability, mTOR signaling, and selective immune cell death.
Ammonia regulates tumor metabolic reprogramming by modulating glutamine metabolism, mitochondrial activity, and lysosomal integrity in neoplastic cells.
Ammonia induces the selective death of immune effector cells, which suppresses anti-tumor immunity and reshapes the tumor microenvironment.
Targeting multi-level ammonia regulatory networks, such as glutamine synthetase and mTOR signaling in combination with immunotherapy, presents a viable multimodal cancer treatment strategy.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/6a0cc5ee291fe4aa62625456 https://doi.org/10.1186/s12964-025-02504-5

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October 30, 2025Cell Communication and SignalingOpen Access

Ammonia metabolism and ammonia-induced cell death: role in cancer therapy

View Full Paper

Ask AI

Bookmark

Authors

YXYan XuCincinnati Children's Hospital Medical Center JWJiafeng WangZhejiang International Studies University AWAiguo WuNingbo University

Discussion

Member takes

Implication

Narrative review uncovers the role of ammonia metabolism and selective immune cell death in the tumor microenvironment, highlighting novel metabolic and immunotherapeutic strategies.

Key Points

To comprehensively evaluate the mechanisms of ammonia metabolism dysregulation, ammonia-induced cell death, and their therapeutic implications in oncology.
Systematically reviewed literature on ammonia generation and clearance pathways, including the urea cycle and tumor glutamine metabolism.
Analyzed the molecular networks linking ammonia accumulation to mitochondrial dysfunction, lysosomal stability, mTOR signaling, and selective immune cell death.
Ammonia regulates tumor metabolic reprogramming by modulating glutamine metabolism, mitochondrial activity, and lysosomal integrity in neoplastic cells.
Ammonia induces the selective death of immune effector cells, which suppresses anti-tumor immunity and reshapes the tumor microenvironment.
Targeting multi-level ammonia regulatory networks, such as glutamine synthetase and mTOR signaling in combination with immunotherapy, presents a viable multimodal cancer treatment strategy.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/6a0cc5ee291fe4aa62625456 https://doi.org/10.1186/s12964-025-02504-5

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