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September 18, 2025Frontiers in ImmunologyOpen Access

Glutamine metabolism and ammonia death: targeted modulation for enhanced cancer immunotherapy

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Authors

FDFei DuLXLinlin XiaoGWGuojun Wang

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Overview

This review explores glutamine's role in ammonia-induced cell death in tumor microenvironments, suggesting implications for immunotherapy optimization.

Key Points

  • Enhanced anti-tumor immune responses can result from integrating cell death mechanisms with immunotherapy.
  • Ammonia death, linked to glutamine metabolism, represents a novel cell death pathway affecting T cells.
  • Targeting ammonia-induced cell death may improve immunotherapy outcomes in diverse cancer types.
  • The review highlights the metabolic contributions of glutamine within the tumor microenvironment.

Cite This Study

Du et al. (2025) studied this question.

synapsesocial.com/papers/68d462d231b076d99fa62591https://doi.org/10.3389/fimmu.2025.1643017
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ammonia metabolism and ammonia-induced cell death: role in cancer therapy2025 · 7 citations
  2. 2Unraveling the role of glutamine metabolism in cancer: from cell death mechanisms to tumor microenvironment modulation2026
  3. 3Lysosome‐Targeted Self‐Adjuvanting Ammonia Nanogenerator Potentiates Hepatocellular Carcinoma Immunotherapy via Ammonia Death2026
  4. 4Prognostic and immunological roles of ammonia-induced cell death-related genes in non-small cell lung cancer2026
  5. 5Ammonia in cancer: dual roles and therapeutic strategies2025