Key result
The TXA2 mimetic IBOP potently antagonized VEGF-induced endothelial cell migration and differentiation (IC50 30 nmol/L), an effect requiring TPbeta expression.
Why the study?
Does Thromboxane A2 receptor stimulation inhibit VEGF-induced endothelial cell differentiation and migration in human endothelial cells?
Population
Human endothelial cells (EC)
Comparison
Thromboxane A2 mimetic IBOP costimulation vs VEGF treatment alone
Design
Preclinical
Authors
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TPβ stimulation may constrain angiogenesis in vitro; leaves open whether antagonism aids revascularization in vivo.
Does Thromboxane A2 receptor stimulation inhibit VEGF-induced endothelial cell differentiation and migration in human endothelial cells?
Effect estimate: IC50 30 nmol/L
Thromboxane A2 receptor stimulation limits angiogenesis by inhibiting VEGF-induced endothelial cell migration and differentiation, suggesting TP antagonism could enhance revascularization.
Ashton et al. (2004) studied Angiogenesis. IBOP (TXA2 mimetic) was evaluated on VEGF-induced endothelial cell migration and differentiation (IC50 30 nmol/L). The TXA2 mimetic IBOP potently antagonized VEGF-induced endothelial cell migration and differentiation (IC50 30 nmol/L), an effect requiring TPbeta expression.
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