Key result
Captopril treatment significantly reduced integrated backscatter from microscopic regions of scar tissue in cardiomyopathic hamsters compared to untreated controls (P=0.0004).
Why the study?
Does captopril alter the material properties of cardiac tissue in experimental cardiomyopathy?
Does captopril alter the material properties of cardiac tissue in experimental cardiomyopathy?
p-value: p=0.0004
Captopril alters the material properties (elastic stiffness, density) of fibrous regions in cardiomyopathic hearts, suggesting a cellular mechanism for its salutary actions in heart failure.
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Captopril may modify scar tissue properties in experimental cardiomyopathy; hypothesis-generating for mechanisms in human HF.
Davison et al. (1994) studied Cardiomyopathy (n=36). Captopril vs. Untreated was evaluated on Integrated backscatter (IB) from microscopic regions of scar tissue (p=0.0004). Captopril treatment significantly reduced integrated backscatter from microscopic regions of scar tissue in cardiomyopathic hamsters compared to untreated controls (P=0.0004).
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