What question did this study set out to answer?

To evaluate the effect of adenosine on vascular proliferation and determine its angiogenic potential in the chick chorioallantoic membrane model.

August 1, 1986Circulation ResearchOpen Access

Stimulation of angiogenesis by adenosine on the chick chorioallantoic membrane.

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Authors

JDJerry W. DusseauWake Forest University PHPhillip M. HutchinsAtrium Health Wake Forest Baptist DMD S Malbasa

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Implication

Controlled laboratory study reveals adenosine stimulates dose-dependent angiogenesis in chick chorioallantoic membranes, suggesting a modulatory role in hypoxia-induced vessel proliferation.

Key Points

To evaluate the effect of adenosine on vascular proliferation and determine its angiogenic potential in the chick chorioallantoic membrane model.
Elvax polymer pellets containing 0.2 to 3.0 mg of adenosine, or mannitol as a control, were placed on chorioallantoic membranes of 10-day-old chick embryos for 4 days.
Vascular density index was measured at 20× magnification on formalin-fixed membranes by counting vessel intercepts with inscribed concentric circles.
Responses were evaluated alongside the metabolite inosine, the antagonist methyl-isobutyl-xanthine (55–110 µg/day), and the uptake inhibitor dipyridamole.
Adenosine stimulated a dose-dependent increase in the vascular density index (p < 0.01), with the 3.0-mg dose inducing a 15% increase, while inosine produced no change.
The adenosine-induced increase in vascularity was partially blocked by 55 µg/day and completely blocked by 110 µg/day of methyl-isobutyl-xanthine.
Dipyridamole enhanced adenosine-stimulated vascular growth by an additional 52%, though it showed no independent effect on vascular density.

Cite This Study

Dusseau et al. (1986) studied this question.

synapsesocial.com/papers/6a0ccd359d761985b14a4d93 https://doi.org/10.1161/01.res.59.2.163

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Implication

Controlled laboratory study reveals adenosine stimulates dose-dependent angiogenesis in chick chorioallantoic membranes, suggesting a modulatory role in hypoxia-induced vessel proliferation.

Stimulation of angiogenesis by adenosine on the chick chorioallantoic membrane.

Discussion

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Implication

Key Points

Cite This Study

Stimulation of angiogenesis by adenosine on the chick chorioallantoic membrane.

Discussion

Member takes

Implication

Key Points

Cite This Study

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