Key result
Avian skeletal muscle myosins are predominantly homodimers of the heavy chain subunit, which is the thermodynamically stable form, with no heterodimeric myosins detected.
This basic science study demonstrates that skeletal muscle myosin heavy chains preferentially assemble into homodimers because they are the thermodynamically stable form, without requiring cellular regulatory processes.
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Myosin homodimerization is thermodynamically driven without regulation; leaves open relevance to mammalian cardiac isoforms.
Kerwin et al. (1991) studied Avian skeletal muscle myosins. Avian skeletal muscle myosins are predominantly homodimers of the heavy chain subunit, which is the thermodynamically stable form, with no heterodimeric myosins detected.
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