Key result
Immunoelectron microscopy demonstrated that two myosin isoforms can exist in an individual thick filament in vivo, with neonatal MHC preferentially decorating the center of heterogeneous filaments.
Demonstrates that two myosin isoforms can coexist in individual thick filaments in vivo and suggests neonatal MHC may play a specific role in fibrillogenesis.
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Does not warrant clinical translation; leaves open developmental roles of isoform mixing in sarcomere assembly.
Taylor et al. (1989) studied Developing chicken pectoral muscle. Colloidal gold-conjugated monoclonal antibodies to stage-specific fast myosin heavy chain isoforms was evaluated on Myosin isoform composition and distribution in thick filaments. Immunoelectron microscopy demonstrated that two myosin isoforms can exist in an individual thick filament in vivo, with neonatal MHC preferentially decorating the center of heterogeneous filaments.
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