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September 15, 1994BloodOpen Access

A point mutation in the integrin beta 3 cytoplasmic domain (S752-->P) impairs bidirectional signaling through alpha IIb beta 3 (platelet glycoprotein IIb-IIIa)

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Authors

YCYP ChenScripps Research InstituteTOTE O'TooleTufts UniversityJYJari YlänneUniversity of Jyväskylä

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Cite This Study

Chen et al. (1994) studied this question.

synapsesocial.com/papers/6a0cd278a4d785ea81625fbdhttps://doi.org/10.1182/blood.v84.6.1857.1857
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers.1990 · 325 citations
  2. 2Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation.1985 · 963 citations
  3. 3Platelet glycoproteins IIb and IIIa: evidence for a family of immunologically and structurally related glycoproteins in mammalian cells.1986 · 149 citations
  4. 4Direct detection of activated platelets and platelet-derived microparticles in humans1990 · 34 citations
  5. 5Human and bovine endothelial cells synthesize membrane proteins similar to human platelet glycoproteins IIb and IIIa.1985 · 127 citations