Key result
Genetic variability between A/J and B6 mice influenced the development of UCP1-positive brown adipocytes in retroperitoneal white fat, but not in interscapular brown fat.
Population
A/J and C57BL/6J (B6) mice (fetus to adult)
Comparison
Observation during development and cold exposure vs Comparison between A/J and C57BL/6J mouse strains
Design
Preclinical
Authors
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Depot-specific genetic control of browning in mice is hypothesis-generating; leaves open human metabolic relevance and therapeutic translation.
Genetic variability between A/J and B6 mice affects the development of brown adipocytes in retroperitoneal white fat but not in interscapular brown fat, suggesting distinct developmental mechanisms.
Xue et al. (2006) studied Brown adipocyte development. A/J mouse strain vs. C57BL/6J (B6) mouse strain was evaluated on Ucp1 expression and brown adipocyte development. Genetic variability between A/J and B6 mice influenced the development of UCP1-positive brown adipocytes in retroperitoneal white fat, but not in interscapular brown fat.
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