Key result
Short-term cold exposure in mice induces depot-specific remodeling, activating brown fat and browning white fat.
Short-term cold exposure in mice induces depot-specific remodeling, expanding and activating brown adipose tissue while inducing browning in subcutaneous and epididymal white adipose tissues.
Temporal profiling of cold-induced adipose browning in mice extends mechanistic insight; leaves open human cardiometabolic translation.
AIM: Brown and beige adipose tissues dissipate energy in the form of heat via mitochondrial uncoupling protein 1, defending against hypothermia and potentially obesity. The latter has prompted renewed interest in understanding the processes involved in browning to realize the potential therapeutic benefits. To characterize the temporal profile of cold-induced changes and browning of brown and white adipose tissues in mice. METHODS: Male C57BL/6J mice were singly housed in conventional cages under cold exposure (4 °C) for 1, 2, 3, 4, 5 and 7 days. Food intake and body weight were measured daily. Interscapular brown adipose tissue (iBAT), inguinal subcutaneous (sWAT) and epididymal white adipose tissue (eWAT) were harvested for histological, immunohistochemical, gene and protein expression analysis. RESULTS: Upon cold exposure, food intake increased, whilst body weight and adipocyte size were found to be transiently reduced. iBAT mass was found to be increased, whilst sWAT and eWAT were found to be transiently decreased. A combination of morphological, genetic (Ucp-1, Pgc-1α and Elov13) and biochemical (UCP-1, PPARγ and aP2) analyses demonstrated the depot-specific remodelling in response to cold exposure. CONCLUSION: Our results demonstrate the differential responses to cold-induced changes across discrete BAT and WAT depots and support the notion that the effects of short-term cold exposure are achieved by expansion, activation and increasing thermogenic capacity of iBAT, as well as browning of sWAT and, to a lesser extent, eWAT.
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Jia et al. (2016) studied Cold-induced adipose tissue remodeling. Cold exposure was evaluated on Temporal profile of cold-induced changes and browning of brown and white adipose tissues. Short-term cold exposure in mice induced depot-specific remodeling, including expansion and activation of interscapular brown adipose tissue and browning of subcutaneous white adipose tissue.
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