Population
Rat retroperitoneal white adipose tissue (rpWAT) model
Comparison
Cold acclimation for 45 days vs Controls maintained at 22 ± 1 °C
Design
Preclinical
Follow-up
45 days
Authors
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May limit sustained thermogenesis from white fat; leaves open whether targeting persistent adipocytes could enhance anti-obesity strategies.
Browning of white adipose tissue during cold acclimation involves a transient non-selective browning followed by the subsistence of only a few thermogenically competent adipocytes, which may impact long-term anti-obesity therapies.
Janković et al. (2015) studied this question.
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