Key result
p-NN'-phenylenebismaleimide acts as a specific cross-linking agent for F-actin, joining subunits of the same long-pitched helix without introducing structural strain.
Population
F-actin (in vitro model)
Design
Preclinical
Authors
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May enable strain-free F-actin studies in vitro; leaves open translation to cardiac myocyte function or disease models.
p-NN'-phenylenebismaleimide acts as a specific cross-linking agent for F-actin subunits within the same long-pitched helix.
Knight et al. (1978) studied F-actin cross-linking. p-NN'-phenylenebismaleimide was evaluated on F-actin cross-linking. p-NN'-phenylenebismaleimide acts as a specific cross-linking agent for F-actin, joining subunits of the same long-pitched helix without introducing structural strain.
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