Key result
Cross-linking of MBS-F-actin to myosin subfragment 1 generated 180-kDa and 140-kDa covalent complexes depending on pH and led to superactivation of MgATPase.
Population
Skeletal myosin subfragment 1 (S-1) and actin derivatives (MBS-G-actin, MBS-F-actin)
Design
Preclinical
Authors
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pH effects on actomyosin cross-linking warrant no clinical change; leaves open relevance to cardiac contractility or MgATPase regulation.
The study demonstrates specific pH-dependent cross-linking of skeletal myosin subfragment 1 to F-actin and G-actin, leading to MgATPase superactivation.
Bettache et al. (1992) studied this question. MBS-F-actin and MBS-G-actin cross-linking to S-1 was evaluated on Formation of actin-heavy chain covalent complexes. Cross-linking of MBS-F-actin to myosin subfragment 1 generated 180-kDa and 140-kDa covalent complexes depending on pH and led to superactivation of MgATPase.
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