Key result
Chemical cross-linking demonstrated that G-actin-S1 and F-actin-S1 complexes display similar electrostatic close contacts, and a change in Cys374 environment is linked to polymerization.
Population
G-actin and myosin subfragment-1 (S1) complexes
Design
Preclinical
Authors
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Does not support changes in cardiovascular practice; leaves open structural mapping of actin-myosin contacts for further study.
This biochemical study maps the interaction sites between G-actin and myosin subfragment-1, revealing structural similarities with F-actin-S1 complexes and highlighting the role of Cys374 during polymerization.
Combeau et al. (1992) studied this question. Chemical cross-linking demonstrated that G-actin-S1 and F-actin-S1 complexes display similar electrostatic close contacts, and a change in Cys374 environment is linked to polymerization.