Population
In vitro biochemical model (G-actin modified with MBS, myosin subfragment 1, tropomyosin-troponin)
Comparison
Chemical modification of G-actin… vs Native F-actin
Design
Preclinical
Authors
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MBS modification impairs Ca2+-dependent thin filament regulation in vitro; leaves open relevance to cardiac contractility or disease models.
Chemical modification of actin with MBS impairs tropomyosin binding and damages the calcium-dependent regulation of acto-S1 ATPase activity by the troponin-tropomyosin complex.
Miki et al. (1991) studied this question.
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