Key result
In conditions with excess free divalent cations, actin subunit exchange kinetics were in better agreement with an exchange-diffusion model than a treadmilling model.
Population
Solutions of F-actin and G-actin
Design
Preclinical
Authors
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Favors exchange-diffusion over treadmilling for actin in vitro; leaves open relevance to cardiac filament dynamics in vivo.
The study proposes a model where a segment of F-actin subunits at one or both ends of the filament contains bound ATP at steady state to rationalize discrepancies between measured and predicted rate constants.
Brenner et al. (1983) studied Actin polymerization kinetics. In conditions with excess free divalent cations, actin subunit exchange kinetics were in better agreement with an exchange-diffusion model than a treadmilling model.
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