October 1, 1984Biochemistry
Cofilin, a protein in porcine brain that binds to actin filaments and inhibits their interactions with myosin and tropomyosin
Key result
Cofilin, a 21,000 MW protein from porcine brain, binds to actin filaments in a 1:1 molar ratio, shortens the filaments, and inhibits their interactions with myosin and tropomyosin.
Authors
Discussion
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Implication
No immediate clinical implications; leaves open cofilin's role in cardiac cytoskeletal regulation.
PICO
I
Intervention / Comparator
Cofilin
Cite This Study
Nishida et al. (1984) studied this question. Cofilin was evaluated. Cofilin, a 21,000 MW protein from porcine brain, binds to actin filaments in a 1:1 molar ratio, shortens the filaments, and inhibits their interactions with myosin and tropomyosin.