Key result
Yeast actin exhibits more rapid rotational motion and restricted angular amplitude compared to muscle actin, suggesting it is less effective at activating myosin due to larger structural changes required.
Yeast actin is less effective at activating myosin due to larger structural changes required upon strong myosin binding compared to muscle actin.
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Caution against extrapolating yeast actin results to human cardiac myosin; leaves open isoform-specific activation mechanisms in mammalian models.
Próchniewicz et al. (1999) studied Actin structural dynamics. Yeast actin vs. Muscle actin was evaluated on Structural dynamics (Time-resolved phosphorescence anisotropy and steady-state fluorescence). Yeast actin exhibits more rapid rotational motion and restricted angular amplitude compared to muscle actin, suggesting it is less effective at activating myosin due to larger structural changes required.
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