Key result
Lowering pH to 6 makes Mg2+-induced actin dimer formation over 2 orders of magnitude more favorable compared to pH 8, and decreases the critical concentration for filament formation.
Population
Rabbit skeletal muscle G-actin
Comparison
Varying pH levels and initial concentrations of… vs Previously proposed mechanism at pH 8
Design
Preclinical
Authors
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Should not yet alter practice; extends biochemical models of actin polymerization for cardiac cytoskeletal research.
Lowering pH from 8 to 6 significantly enhances Mg2+-induced actin dimer formation and decreases the critical concentration for filament formation in rabbit skeletal muscle G-actin.
Zimmerle et al. (1988) studied this question. pH variation (pH 6 to 7.5) vs. pH 8 was evaluated on Actin polymerization kinetics. Lowering pH to 6 makes Mg2+-induced actin dimer formation over 2 orders of magnitude more favorable compared to pH 8, and decreases the critical concentration for filament formation.
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