Key result
Two classes of cation binding sites were found on G-actin: a single high-affinity site with a Kd < 1 microM and three identical moderate-affinity binding sites with a Kd of 18 microM.
Population
skeletal muscle G-actin
Design
Preclinical
Authors
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Delineates cation sites on G-actin; hypothesis-generating for actin regulation and requires validation before clinical relevance.
G-actin possesses distinct high- and moderate-affinity binding sites for divalent cations, which induce specific conformational changes upon binding.
Zimmerle et al. (1987) studied this question. Divalent cations was evaluated on Cation binding sites on G-actin. Two classes of cation binding sites were found on G-actin: a single high-affinity site with a Kd < 1 microM and three identical moderate-affinity binding sites with a Kd of 18 microM.
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