Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys
Authors
Discussion
Loading...
Member takes
Implication
Randomized trial examines gene expression in aging and caloric restriction in rhesus monkeys, indicating species-specific responses.
Key Points
- This research investigates how aging and caloric restriction affect gene expression in skeletal muscle of rhesus monkeys.
- Analyzed gene expression profiles of 7,070 genes in the vastus lateralis muscle from young (8 years) and aged (26 years) monkeys.
- Compared mid-aged monkeys (20 years) subjected to caloric restriction since 11 years with age-matched controls.
- Used high-density oligonucleotide arrays for gene expression analysis.
- Aging led to increased inflammation and oxidative stress gene expression while down-regulating mitochondria-related genes.
- Caloric restriction up-regulated cytoskeletal protein genes but did not significantly alter age-related gene expression changes.
- Findings suggest species-specific differences in how caloric restriction influences aging-related transcriptional responses.
Cite This Study
Kayo et al. (2001) studied this question.