Transcriptional profiles associated with aging and middle age-onset caloric restriction in mouse hearts
Key result
Caloric restriction initiated at 14 months of age resulted in a 19% global inhibition of age-related changes in gene expression in the mouse heart.
Why the study?
Does caloric restriction started in middle age alter age-related transcriptional profiles in mouse hearts?
Population
5- and 30-month-old male B6C3F(1) mice
Comparison
Caloric restriction started at 14 months of age vs Normal aging without caloric restriction
Design
Preclinical
Follow-up
Until 30 months of age
Authors
Discussion
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Implication
Supports caloric restriction modulating cardiac aging in mice; leaves open translation to human middle-age interventions.
Structured PICO
Does caloric restriction started in middle age alter age-related transcriptional profiles in mouse hearts?
P
Population
5- and 30-month-old male B6C3F(1) mice
I
Intervention
Caloric restriction (CR) started at 14 months of age
C
Comparator
Normal aging without caloric restriction
O
Outcome
Global analysis of gene expression (9,977 genes) using high-density oligonucleotide microarrayssurrogate
Limitations
- Alterations in gene expression observed with aging or caloric restriction may be associated with changes in cell populations in the heart rather than purely intracellular transcriptional changes.
Cite This Study
Lee et al. (2002) studied Aging (n=15). Caloric restriction vs. Control diet (98 kcal/week) was evaluated on Global inhibition of age-related changes in gene expression. Caloric restriction initiated at 14 months of age resulted in a 19% global inhibition of age-related changes in gene expression in the mouse heart.