What question did this study set out to answer?

To evaluate the reliability, clinical utility, and accessibility of nTMS, MEG, and fMRI for preoperative motor and language mapping in patients undergoing brain tumor surgery.

January 7, 2025Frontiers in OncologyOpen Access

Preoperative mapping techniques for brain tumor surgery: a systematic review

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Authors

ALAugusto LeoneStädtisches Klinikum Karlsruhe FCFrancesco CarboneUniversity of Foggia USUwe SpetzgerKarlsruhe Institute of Technology

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Implication

Systematic review reveals navigated transcranial magnetic stimulation outperforms fMRI in motor mapping for brain tumor surgery, suggesting superior utility in guiding surgical strategy.

Key Points

To evaluate the reliability, clinical utility, and accessibility of nTMS, MEG, and fMRI for preoperative motor and language mapping in patients undergoing brain tumor surgery.
Conducted a systematic review following PRISMA guidelines across multiple biomedical literature databases.
Analyzed 128 studies meeting eligibility criteria, comprising 48 nTMS, 56 fMRI, and 24 MEG investigations.
Navigated transcranial magnetic stimulation demonstrated high safety, standardization, and accuracy comparable to direct cortical stimulation for motor mapping, particularly when combined with tractography for deficit prediction.
Functional MRI demonstrated substantial limitations in surgical planning due to false positives from co-activated non-essential areas and false negatives from neurovascular uncoupling.
Language mapping demonstrated notable variability across all modalities relative to direct cortical stimulation, although repetitive nTMS provided valuable negative predictive value to inform awake versus asleep surgery decisions.

Cite This Study

Leone et al. (2025) studied this question.

synapsesocial.com/papers/6a0ce9ed0f2e12c3ee1f593e https://doi.org/10.3389/fonc.2024.1481430

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Implication

Systematic review reveals navigated transcranial magnetic stimulation outperforms fMRI in motor mapping for brain tumor surgery, suggesting superior utility in guiding surgical strategy.

Preoperative mapping techniques for brain tumor surgery: a systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

Preoperative mapping techniques for brain tumor surgery: a systematic review

Discussion

Member takes

Implication

Key Points

Cite This Study

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