Key result
Histamine induces a rapid, sustained rise in parietal cell lasp-1 phosphorylation and partial redistribution, suggesting lasp-1 regulates dynamic actin-based cytoskeletal activities.
Population
Gastric parietal cells, primary cultures of gastric fibroblasts, and various other tissue types
Comparison
Histamine (cAMP-dependent acid secretory agonist) vs Unstimulated cells
Design
Preclinical
Authors
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Findings in rodent parietal cells should not alter clinical practice; leaves open lasp-1 as regulator of actin dynamics in human epithelia.
Lasp-1 plays an important role in regulating dynamic actin-based cytoskeletal activities and may link cAMP signaling with membrane restructuring in ion-transporting epithelia.
Chew et al. (2000) studied Ion transport and cytoskeletal dynamics. Histamine (cAMP-dependent acid secretory agonist) vs. Unstimulated cells was evaluated on lasp-1 phosphorylation and cellular redistribution. Histamine induces a rapid, sustained rise in parietal cell lasp-1 phosphorylation and partial redistribution, suggesting lasp-1 regulates dynamic actin-based cytoskeletal activities.
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