Key result
Genetic mutations in sarcomere proteins and metabolic pathways drive heart failure and cardiomyopathy progression.
This review highlights the genetic and hereditary factors contributing to heart failure and cardiomyopathies, noting the need for further research into pathophysiological mechanisms and gene therapies.
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May support genetic evaluation in cardiomyopathies; leaves open targeted therapies pending prospective validation.
Li et al. (2016) conducted a review in Heart failure and myocardial dysfunction. Genetic factors, including mutations in sarcomere proteins and metabolic pathways, play a significant role in the development and progression of heart failure and cardiomyopathies.
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