Key result
Cardiac fibroblast-myocyte signaling pathways, involving paracrine signals and direct/indirect interactions, play crucial roles in cardiac development and remodeling during disease progression.
Understanding the communication signals between cardiac fibroblasts and myocytes, potentially including vascular endothelial growth factor B, may offer insights into promoting cardiac function in compromised hearts.
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May inform antifibrotic strategies in remodeling; leaves open clinical translation pending targeted trials.
Ottaviano et al. (2011) conducted a review in Cardiac remodeling and disease progression. Cardiac fibroblast-cardiac myocyte signaling pathways was evaluated. Cardiac fibroblast-myocyte signaling pathways, involving paracrine signals and direct/indirect interactions, play crucial roles in cardiac development and remodeling during disease progression.
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