Key result
Circulating thrombopoietin levels in ITP patients were mildly elevated (1.86 fmol/ml) compared to normal subjects (0.76 fmol/ml) but much lower than in aplastic anemia (12.35 fmol/ml).
Why the study?
Are circulating thrombopoietin levels elevated in patients with chronic immune thrombocytopenic purpura compared to normal subjects and those with aplastic anaemia?
Population
43 patients with chronic immune thrombocytopenic purpura, along with normal subjects and patients with…
Comparison
Measurement of circulating thrombopoietin level… vs Normal subjects and patients with aplastic anaemia
Design
Cross-sectional
Authors
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May support relative TPO deficiency in ITP thrombocytopenia; hypothesis-generating for TPO agonists in chronic disease.
Observational (n=43)
Are circulating thrombopoietin levels elevated in patients with chronic immune thrombocytopenic purpura compared to normal subjects and those with aplastic anaemia?
Absolute Event Rate: 1.86% vs 0.76%
Relative endogenous TPO deficiency may play a role in the pathophysiology of thrombocytopenia in ITP patients, as their TPO levels are only mildly elevated compared to the massive increase seen in aplastic anemia.
Kosugi et al. (1996) conducted an observational in Chronic immune thrombocytopenic purpura (ITP) (n=43). Circulating thrombopoietin (TPO) level measurement vs. Normal subjects and patients with aplastic anaemia was evaluated on Circulating thrombopoietin (TPO) level. Circulating thrombopoietin levels in ITP patients were mildly elevated (1.86 fmol/ml) compared to normal subjects (0.76 fmol/ml) but much lower than in aplastic anemia (12.35 fmol/ml).
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