Key result
Inflammatory bowel disease linked to markedly higher serum thrombopoietin levels versus healthy controls.
Why the study?
Elevated platelet count is a recognized marker of IBD activity, but the relationship between thrombopoietin levels and IBD clinical characteristics was unclear.
Are serum levels of endogenous Thrombopoietin (TPO) elevated in patients with inflammatory bowel disease compared to healthy controls?
Population
40 Crohn's disease patients, 63 ulcerative colitis patients, and 42 healthy blood donors
Comparison
IBD patients vs healthy blood donors
Design
Case-control study
Authors
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Elevated TPO may contribute to IBD procoagulant state; hypothesis-generating for causality and therapeutic targeting.
Case-Control (n=145)
Are serum levels of endogenous Thrombopoietin (TPO) elevated in patients with inflammatory bowel disease compared to healthy controls?
p-value: p=< 0.0001
Thrombopoietin levels are significantly elevated in patients with inflammatory bowel disease regardless of disease activity or platelet counts, suggesting a potential role in the procoagulant state of IBD.
Kapsoritakis et al. (2000) conducted a case-control in Inflammatory Bowel Disease (n=145). Inflammatory Bowel Disease vs. Healthy blood donors was evaluated on Serum levels of endogenous thrombopoietin (TPO) (p=< 0.0001). Inflammatory bowel disease was associated with significantly elevated serum thrombopoietin levels in Crohn's disease (124.3 pg/ml) and ulcerative colitis (152.2 pg/ml) vs controls (53.4 pg/ml; p<0.0001).