January 1, 2007Platelets

Thrombopoietin is not uniquely responsible for thrombocytosis in inflammatory disorders

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Population

Patients hospitalized for acute illnesses, including a group with strong elevation of erythrocyte…

Design

Cross-sectional

Authors

ICIride Francesca CeresaVivantes Klinikum PNPatrizia NorisUniversity of Siena CAChiara AmbaglioOspedale Papa Giovanni XXIII

Discussion

Member takes

Implication

TPO elevation does not drive reactive thrombocytosis alone; leaves open cooperative IL-6 roles in acute-phase inflammation.

Structured PICO

Population

Patients hospitalized for acute illnesses, including a group with strong elevation of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) (n=53; 38 with normal platelet counts, 15 with thrombocytosis) and a control group with normal ESR and CRP values.

Comparator

Control patients hospitalized for acute illnesses with normal ESR and CRP values.

Outcome

TPO levels and platelet countssurrogate

TPO acts as an acute phase protein but is not uniquely responsible for reactive thrombocytosis in inflammatory disorders, with IL-6 likely acting as a cooperating factor.

Cite This Study

Ceresa et al. (2007) studied this question.

synapsesocial.com/papers/6a736b8796bd0fc833c1e5e4 https://doi.org/10.1080/09537100701593601

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Thrombopoietin is not uniquely responsible for thrombocytosis in inflammatory disorders

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Thrombopoietin is not uniquely responsible for thrombocytosis in inflammatory disorders

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider