Key result
Hip replacement surgery resulted in a peak in plasma TPO levels on the 3rd day, which preceded the platelet peak by 11 days and correlated with ESR (P=0.012) and CRP (P=0.033).
Population
12 patients undergoing hip replacement surgery and 30 healthy donors
Design
Cohort
Follow-up
45 days
Authors
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TPO may act as acute-phase reactant after hip replacement; extends prior reactive thrombocytosis observations but leaves clinical implications open.
Observational (n=42)
Effect estimate: r = 0.975
p-value: p=<0.00001
In reactive conditions such as post-surgery, thrombopoietin behaves like an acute phase reactant, with an early rise preceding the increase in platelet count.
Cerutti et al. (1999) conducted an observational in Reactive conditions (post-hip replacement surgery) (n=42). Hip replacement surgery vs. Healthy donors was evaluated on Correlation between serum and plasma TPO (r = 0.975, p=<0.00001). Hip replacement surgery resulted in a peak in plasma TPO levels on the 3rd day, which preceded the platelet peak by 11 days and correlated with ESR (P=0.012) and CRP (P=0.033).
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