Population
Patients that underwent major surgery, and in vitro HepG2 liver cell line
Design
Cohort
Authors
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IL-6 may drive post-operative thrombocytosis via Tpo; hypothesis-generating for cytokine-targeted trials but should not change practice.
Post-operative thrombocytosis is likely driven by increased thrombopoietin production, which may be stimulated by inflammatory cytokines such as IL-6.
Folman et al. (2001) studied this question.
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