Acetylsalicylic acid 300 mg for 7 days reduced the proportion of high-intensity transient signals to 0% compared to 50% with standard heart failure treatment alone (p=0.028).
RCT (n=12)
Open-label, blinded endpoint
2:1
Does acetylsalicylic acid reduce the proportion of high-intensity transient signals in patients with Chagasic heart failure?
In a pilot trial of patients with Chagasic heart failure, a 7-day course of aspirin 300 mg significantly reduced the proportion of cerebral microemboli detected by transcranial Doppler.
Absolute Event Rate: 0% vs 50%
p-value: p=0.028
Abstract Chagas disease is an important cause of heart failure (HF) and stroke, affecting over 6 million people. High-intensity transient signals (HITS) are detected on transcranial Doppler (TCD) in patients with Chagas disease, but the effect of antithrombotic treatment on HITS is unknown. To evaluate whether acetylsalicylic acid (ASA) reduces the frequency and number of HITS in patients with Chagasic HF. Proof-of-principle pilot prospective, randomized, open, blinded endpoint (PROBE) clinical trial, in which patients with both Chagas and HITS were randomized 2:1 to ASA 300 mg for 7 days and standard HF treatment or standard HF treatment alone (control group). The primary outcome was the proportion of HITS after one week, analyzed using the Chi-squared test. A total of 373 patients with HF were evaluated, with HITS occurring in 22/190 (12%) Chagasic patients and in 16/183 (8%) non-Chagasic patients (p = 0.531). Twelve of the 22 (54%) Chagasic patients were randomized to treatment with (n = 8) or without ASA (n = 4). Two patients in the control group (50%) persisted with HITS after 7 days of treatment, compared to none in the ASA group, p = 0.028. The median number of HITS decreased from 3.5 to 0 with ASA (p = 0.012) and 4.0 to 0.5 in the control group (p = 0.095), with no significant between-group difference (p = 0.262). No adverse events were reported. In the present pilot clinical trial, ASA reduced the proportion of HITS in patients with Chagas disease HF.
Branco et al. (Wed,) conducted a rct in Chagasic heart failure with high-intensity transient signals (HITS) (n=12). Acetylsalicylic acid (ASA) vs. Standard heart failure treatment alone was evaluated on Proportion of HITS after one week (p=0.028). Acetylsalicylic acid 300 mg for 7 days reduced the proportion of high-intensity transient signals to 0% compared to 50% with standard heart failure treatment alone (p=0.028).