What question did this study set out to answer?

To determine the effect of low-dose acetylsalicylic acid on cardiac events in patients suspected of acute myocardial infarction.

November 1, 1989Journal of Internal Medicine

Acetylsalicylic acid 100 mg and 1000 mg daily in acute myocardial infarction suspects: a placebo‐controlled trial

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Why the study?

Does acetylsalicylic acid 100 mg or 1000 mg daily reduce the combined incidence of cardiac death and non-fatal myocardial infarction in patients with possible acute myocardial infarction?

Population

293 patients admitted to the coronary care unit with acute chest pain, possible acute myocardial infarction…

Comparison

Acetylsalicylic acid 100 mg daily or 1000 mg… vs Placebo for 3 months

Design

RCT, randomized, placebo-controlled

Follow-up

3 months

Authors

SHSteen HustedUniversity of Copenhagen HNHans Kræmmer NielsenAarhus University LKLars Romer KrusellInterventional / Structural Cardiology

Discussion

Member takes

Implication

Low-dose aspirin reduces early cardiac events in suspected MI; reinforces preference for low-dose over high-dose antiplatelet regimens in ACS.

Key Points

To determine the effect of low-dose acetylsalicylic acid on cardiac events in patients suspected of acute myocardial infarction.
Randomized placebo-controlled trial involving 293 patients with suspected myocardial infarction (N=1078).
Participants received acetylsalicylic acid 100 mg, 1000 mg, or placebo for 3 months.
Incidence of cardiac death and non-fatal myocardial infarction was measured.
The 100 mg group had a significantly lower incidence of cardiac events (7.1%) compared to the 1000 mg group (20.8%) and placebo (19.7%) with P < 0.02.
During follow-up, trends favored the 100 mg treatment, but differences were not statistically significant when including withdrawals.
Collagen-induced platelet aggregation and serum thromboxane B2 levels were reduced in both ASA groups but normal in the placebo group.

Structured PICO

Does acetylsalicylic acid 100 mg or 1000 mg daily reduce the combined incidence of cardiac death and non-fatal myocardial infarction in patients with possible acute myocardial infarction?

Population

293 patients admitted to the coronary care unit with acute chest pain, possible acute myocardial infarction, and symptoms of median 4 h duration

Intervention

Acetylsalicylic acid 100 mg daily or 1000 mg daily for 3 months

Comparator

Placebo for 3 months

Outcome

Combined incidence of cardiac death and non-fatal myocardial infarction during hospitalizationcomposite

Low-dose (100 mg) acetylsalicylic acid significantly reduced the on-treatment incidence of cardiac death and non-fatal MI during hospitalization compared to high-dose (1000 mg) and placebo in patients with suspected acute MI.

Limitations

Differences were not statistically significant when analyzed according to the intention-to-treat principle (withdrawals included)

Cite This Study

Husted et al. (1989) studied this question.

synapsesocial.com/papers/6a71a4c078a11c550e0ba9ce https://doi.org/10.1111/j.1365-2796.1989.tb01400.x

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Implication

Low-dose aspirin reduces early cardiac events in suspected MI; reinforces preference for low-dose over high-dose antiplatelet regimens in ACS.

Acetylsalicylic acid 100 mg and 1000 mg daily in acute myocardial infarction suspects: a placebo‐controlled trial

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Acetylsalicylic acid 100 mg and 1000 mg daily in acute myocardial infarction suspects: a placebo‐controlled trial

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider